Epilepsy is a chronic neurological illness characterized by recurring seizures caused by aberrant electrical activity in the brain. Although there is no treatment for epilepsy, there are several techniques for managing its impact on people’s lives. This blog aims to explore what is the effectiveness of CBD products in epilepsy.
Research on CBD and Epilepsy
CBD, a compound present in cannabis, reduces seizures in numerous treatment-resistant forms of pediatric epilepsy in a manner that was previously unknown, according to a study.
Under the direction of researchers from NYU Grossman School of Medicine, the new study discovered that CBD inhibited the transmission of signals conveyed by the molecule lysophosphatidylinositol (LPI). LPI, which is present in neurons (brain cells), is believed to amplify nerve signals normally; however, it can be manipulated by disease to induce convulsions.
The Experiment
Treatment of mice with CBD derived from plants prior to exposure to stimuli that induce seizures or genetic modification to eliminate GPR55 prevented LPI-mediated effects on excitatory and inhibitory synaptic transmission, according to the findings of the research team. Although previous research had suggested that GPR55 may be a target of CBD for reducing seizures, the current study proposed a more comprehensive mechanism of action.
According to the authors, CBD inhibits a “positive feedback loop” in which seizures stimulate LPI–GPR55 signaling, which presumably promotes additional seizures that raise LPI and GPR55 levels. Further research is required to corroborate the applicability of the vicious cycle hypothesis as a possible explanation for recurrent epileptic seizures.
Additionally, the present investigation explored the cannabinoid CBD derived from plants. However, the authors acknowledge that LPI is a component of a signaling network that encompasses naturally occurring “endocannabinoids” such as 2-arachidonoylglycerol (2-AG) found in human tissues. While CBD also regulates 2-AG and LPI target receptors, their synapse-specific effects are distinct. In contrast to LPI, which amplifies incoming electrical signals, endocannabinoids such as 2-AG inhibit the release of neurotransmitters from nerve cells in response to increased cerebral activity. Intriguingly, enzymes are capable of converting LPI and 2-AG to one another.
A History of Epilepsy
When exactly did epilepsy first become apparent? Epilepsy has afflicted the human species throughout history. The Sakikku, a medical text dating back 3,000 years, contains the initial comprehensive account of the ailment. Approximately 1,050 BC, the Babylonians (an ancient civilization in modern-day Iraq) authored this work. The Sakikku endeavored to delineate every recognized ailment.
The stone tablets contain a description of a disease known as Sakkikumiqtu, which translates to “falling sickness.” This is the earliest known description of the disease in the annals of epilepsy. While acknowledging the existence of various types of seizures, the authors assigned each one a distinct spirit.
Epilepsy in ancient China and India
During the approximate period of 400 BC, an ancient Indian medical manuscript known as the Charaka Samhita provided an accurate account of convulsive episodes characterized by concurrent occurrences of blackout and loss of consciousness. Significantly, this approach demonstrated an ability to identify that the origin of seizures were within the cerebral region.
During a contemporaneous era, textual sources within the realm of traditional Chinese medicine commenced elucidating the phenomenon of epilepsy. Similar to the ancient Indian civilization, the Chinese population also recognized that seizures were rooted in physiological factors within the human body. Consequently, they held the belief that acupuncture might serve as a viable method for addressing this ailment.
Some Key CBD Products in Epilepsy Disease
Let us now look at specific CBD products in epilepsy disease and their impact and consequences:
Canna Slim:
Canna Slim is a CBD product that promotes general well-being. While not specifically marketed for epilepsy, CBD’s potential relaxing and stress-relieving effects may aid in the management of conditions that can cause seizures in some people.
CBD Oil Tincture:
CBD oil tinctures are a popular and adaptable method of consuming CBD. Their sublingual administration allows for rapid absorption, potentially offering immediate relief from epilepsy symptoms. Regular use may aid in the maintenance of a steady amount of CBD in the body, providing ongoing support. That means this is also among the key CBD products in epilepsy.
CBD + THC Oil:
Combining CBD with THC (tetrahydrocannabinol) results in a product that combines the medicinal benefits of both cannabinoids. This product is known as CBD + THC Oil. THC, which is known for its euphoric effects, may help CBD’s anticonvulsant properties. However, individual sensitivities and the legal ramifications of THC use must be considered.
Sleep PM:
Quality sleep is essential for overall health, and people with epilepsy may struggle to get enough rest. CBD products meant to induce relaxation and increase sleep quality, such as Sleep PM, may indirectly contribute to epilepsy management by addressing a potential trigger. Therefore, it can be listed down as one of the CBD products in epilepsy.
THC-Free Tincture:
For individuals looking for the advantages of CBD without the psychoactive effects of THC, a THC Free Tincture is a possible option. This medication provides the possible anticonvulsant qualities of CBD while avoiding the euphoric effects of THC.
Anxiety Tincture 1,000mg:
Epilepsy and anxiety illnesses frequently coexist. 1,000mg Anxiety Tincture combined with CBD may provide a double benefit by alleviating anxiety symptoms while also potentially aiding in seizure treatment.
Full Spectrum CBD Capsules:
Full Spectrum CBD Capsules contain a variety of cannabinoids, terpenes, and other helpful chemicals extracted from the cannabis plant. This comprehensive approach seeks to capitalize on the synergistic effects of various components, potentially improving the therapeutic impact on epilepsy.
D9 Peanut Butter Nugs:
While the name may conjure up a humorous image, D9 Peanut Butter Nugs are likely to contain Delta-9 THC, the psychoactive component of cannabis. Given the potential legal consequences and the influence of THC on epilepsy, it’s critical to approach such items with prudence.
Conclusion
In conclusion, the interaction between CBD and epilepsy is an area of continuing research, with promising results indicating a potential role in seizure treatment. Individual responses to CBD, however, vary, and patients with epilepsy should check with healthcare specialists before introducing CBD products in epilepsy into their treatment plans. Furthermore, recognizing the distinctive characteristics of different CBD products enables consumers to make informed decisions based on their individual needs and preferences.